发明名称 |
Anti-HBs monoclonal antibodies |
摘要 |
An anti-HBs monoclonal antibody is described herein. This antibody can bind to the following: (i) a wild type HBsAg; (ii) at least one mutant HBsAg selected from the group consisting of a first mutant HBsAg and a second mutant HBsAg; and (iii) at least one mutant HBsAg selected from the group consisting of a third mutant HBsAg and a fourth mutant HBsAg. The first mutant HBsAg has a mutation at position 120. The second mutant HBsAg has a mutation at position 141. The third mutant HBsAg has a substitution to a lysine at position 118. The fourth mutant HBsAg has only one mutation at position 144 and an amino acid at the position 144 is substituted by a glutamic acid. |
申请公布号 |
EP1724285(B1) |
申请公布日期 |
2009.08.12 |
申请号 |
EP20060010062 |
申请日期 |
2006.05.16 |
申请人 |
SYSMEX CORPORATION |
发明人 |
TAKEDA, KAZUHIKO;KAJITA, TADAHIRO;ASAEDA, AYUMI |
分类号 |
C07K16/08;C07K14/02;C12N5/20;G01N33/569 |
主分类号 |
C07K16/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|