发明名称 |
SUBMICRON NANOPARTICLE OF POORLY WATER SOLUBLE CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARATION THEREOF |
摘要 |
The present invention relates to a nanoparticle composition comprising a camptothecin derivative, solid polyethyleneglycol and an anti-associative agent, and the process for preparing the same. Specifically, the present invention provides a composition comprising a nanoparticle of the camptothecin derivative, which is prepared by solid-dispersing the poorly water soluble camptothecin derivative in polyethyleneglycol and dissolving the solid dispersions in an aqueous solution containing an anti-associative agent. The composition of the present invention stabilizes the camptothecin derivative lactone form in body fluid for effective anticancer activity. |
申请公布号 |
EP2086513(A1) |
申请公布日期 |
2009.08.12 |
申请号 |
EP20070808368 |
申请日期 |
2007.09.20 |
申请人 |
SAMYANG CORPORATION |
发明人 |
KANG, HYE WON;YIM, EUN YOUNG;SEO MIN HYO |
分类号 |
A61K9/16;A61K9/00;A61K9/14;A61K9/19 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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