发明名称 |
ALK1 RECEPTOR AND LIGAND ANTAGONISTS AND USES THEREOF |
摘要 |
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction. |
申请公布号 |
EP2087001(A2) |
申请公布日期 |
2009.08.12 |
申请号 |
EP20070861684 |
申请日期 |
2007.11.02 |
申请人 |
ACCELERON PHARMA, INC. |
发明人 |
GRINBERG, ASYA;KNOPF, JOHN;KUMAR, RAVINDRA;PEARSALL, ROBERT SCOTT;SEEHRA, JASBIR |
分类号 |
C07K14/71 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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