发明名称 USE OF LOW DOSES OF OLIGONUCLEOTIDES ANTISENSE TO TGF-BETA, VEGF, INTERLEUKIN-10, C-JUN, C-FOS OR PROSTAGLANDIN E2 GENES IN THE TREATMENT OF TUMORS
摘要 Use of at least one oligonucleotide with a length of from 8 to 30 nucleotide building blocks for manufacturing a pharmaceutical preparation for the prophylaxis and/or the treatment of diseases, that are modulated by TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos, and/or prostaglandin E2 in a mammal, wherein said oligonucleotide hybridizes with a messenger RNA of a TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos and/or prostaglandin E2 gene and wherein said preparation comprises said oligonucleotide in a concentration of about 1 microM to about 25 microM.
申请公布号 EP2062586(A3) 申请公布日期 2009.08.12
申请号 EP20080173070 申请日期 2006.05.04
申请人 ANTISENSE PHARMA GMBH 发明人 SCHLINGENSIEPEN, KARL-HERMANN;SCHLINGENSIEPEN, REIMAR
分类号 A61K31/7125;A61P25/00;A61P37/06;C12N15/11;C12N15/113 主分类号 A61K31/7125
代理机构 代理人
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