Induction of an immune response against Dengue virus using prime-boost approach

摘要

The invention relates to a method of inducing an immune response to dengue virus comprising administering a priming dengue virus immunogen and boosting with a heterologous dengue virus immunogen wherein: a. said priming dengue virus immunogen is selected from the group consisting of: i) a DNA expression system; ii) an adenovirus expression vector; and iii) a Venezuelan equine encephalitis virus replicon system; b. said boosting dengue virus immunogen is selected from the group consisting of: i) an adenovirus expression vector; and ii) a Venezuelan equine encephalitis virus replicon system.