发明名称 |
ENZYMATIC RESOLUTION OF SUBSTITUTED 2-METHYL-PROPIONIC ACID |
摘要 |
Provided are enzymatic methods for the selective hydrolytic resolution of ce rtain enantiomers of a pharmaceutical compound, the pharmaceutical compound comprising a ( ) mixture of a .alpha.-substituted 2- methyl propionic acid derivative. Specifically provided is the selective enzymatic resolution of either the R(+) or S(-) enantiomer of ( )- ethyl ciprofibrate. Also provided are substantially pure enantiomers of R(+) and S(-) ciprofibrate.
|
申请公布号 |
CA2183449(C) |
申请公布日期 |
2009.08.11 |
申请号 |
CA19952183449 |
申请日期 |
1995.02.13 |
申请人 |
|
发明人 |
CHASE, MATTHEW W.;GOODHUE, CHARLES T.;SEEMAYER, ROBERT;WHITED, GREGORY M. |
分类号 |
C12P41/00;C12P7/40;C12P7/52;C12P7/62;C12P13/00 |
主分类号 |
C12P41/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|