WAY OF MODELLING OF HEPATIC ENCEPHALOPATHY

摘要

FIELD: medicine. ^ SUBSTANCE: invention concerns area of experimental medicine, namely to experimental hepathology and can be used for modeling of hepatic encephalopathy. For this purpose four-chloride carbon is used in a combination with liquid paraffin in the ratio 1:1. The admixture is administered unitary weekly within 4-6 weeks. The model of hepatic encephalopathy is considered to be reached in presence of the expressed dystrophic process in hepatocytes, in vascular system and bile ducts of hepatoportal tracts, and at time decrease of rats' runway up to 100 - 150 s on distance of 30 cm on the seventh-eighth combination of a conditional and unconditional stimulus. ^ EFFECT: adequate replication of the model. ^ 3 ex