发明名称 |
AN ANTI-CANCER CYTOTOXIC MONOCLONAL ANTIBODY |
摘要 |
<p>The present invention relates to a method for producing cancerous disease modifying antibodies (CDMAB). Antibodies generated in mice, upon immunization with malignant cells of human lung adenocarcinoma tumour tissue are screened for cytotoxicity against a variety of cancer cell lines. An anti-cancer cytotoxic monoclonal antibody (mAb) is isolated, produced by the hybridoma AR99A184. 3 deposited with IDAC as Accession Number 120907-03, which is cytotoxic to human lung cancer cell lines, and reduces tumour burden in a human breast cancer xenograft model. The mAb also binds to several cancer cell lines but is not cytotoxic in a non-cancerous cell line. This mAb can be used to treat primary tumours and tumour metastases. This mab can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.</p> |
申请公布号 |
WO2009094752(A1) |
申请公布日期 |
2009.08.06 |
申请号 |
WO2009CA00064 |
申请日期 |
2009.01.22 |
申请人 |
F. HOFFMANN-LAROCHE AG;YOUNG, DAVID S. F.;FINDLAY, HELEN P.;HAHN, SUSAN E.;POPP, LISA A. |
发明人 |
YOUNG, DAVID S. F.;FINDLAY, HELEN P.;HAHN, SUSAN E.;POPP, LISA A. |
分类号 |
C07K16/30;A61K39/395;A61K47/48;A61K51/10;A61P35/00;A61P37/04;C07K16/28;C07K16/46;C12N5/16;C12P21/08;G01N33/574;G01N33/577 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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