发明名称 |
USE OF HEDGEHOG AGONISTS IN THE TREATMENT OF MUSCULOSKELETAL-RELATED DISORDERS |
摘要 |
<p>The invention provides methods for the diagnosis and treatment of musculoskeletal disorders relating to the Hedgehog pathway, including but not limited to muscular dystrophy (e.g., Duchenne Muscular Dystrophy) using agents that agonize Sonic Hedgehog (shh), and thereby, the Hedgehog signaling pathway. Said agonizing agents include, e.g., the compounds of the invention (e.g., a compound of Formula I). The invention also provides methods of screening for agents that are capable of increases the proliferation of muscle and/or muscle precursor cells.</p> |
申请公布号 |
WO2009095378(A1) |
申请公布日期 |
2009.08.06 |
申请号 |
WO2009EP50868 |
申请日期 |
2009.01.27 |
申请人 |
NOVARTIS AG;ARMSTRONG, DUSTIN DONALD;KADAM, SHILPA |
发明人 |
ARMSTRONG, DUSTIN DONALD;KADAM, SHILPA |
分类号 |
A61K31/00;A61K31/4436;A61P21/00;G01N33/15 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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