发明名称 |
2'-Modified Oligonucleotides |
摘要 |
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
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申请公布号 |
US2009198047(A1) |
申请公布日期 |
2009.08.06 |
申请号 |
US20070764087 |
申请日期 |
2007.06.15 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK PHILLIP DAN;KAWASAKI ANDREW MAMORU |
分类号 |
C07H21/02;A61K38/00;A61K48/00;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/00;C07H21/04;C07H23/00;C07J43/00;C12N9/02;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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