MEANS FOR DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS

摘要

The present invention relates to oligonucleotide pairs (primers) allowing amplification of CDR3-Vbeta- Jbeta regions of TCR to rheumatoid arthritis, a method for diagnosis and/or monitoring of said disease using said oligonucleotides, a diagnostic kit for diagnosis and/or monitoring of rheumatoid arthritis comprising said oligonucleotides, nucleotide sequences amplified from said oligonucleotides as rheumatoid arthritis markers, amino acid sequences encoded by said nucleotide sequences, having such amino acid sequences as rheumatoid arthritis markers and the peptides themselves, together with one or more immunostimulant adjuvants and pharmacologically acceptable excipients, as polypeptide vaccines against rheumatoid arthritis.