METHOD OF DETERMINING BREAST CANCER RISK

摘要

The invention provides methods and reagents related to a chromosomal loci associated with altered risk for developing breast cancer. The method includes screening genomic sequence information for the presence or absence of one or more polymorphism alleles in chromosome 6q22.33 that indicates a lower risk of developing breast cancer in the subject or an increased risk of developing breast cancer in the subject. The invention also provides related machine readable media and methods of screening for a candidate therapeutic compound for breast cancer. The invention also provides an oligonucleotide or set of oligonucleotides that selectively anneal to genomic DNA comprising one, but not both, of the rs2180341, rs6569479, rs6569480, or rs7776136 SNP alleles. The oligonucleotide or set of oligonucleotides can be provided in kits that also include reagents suitable for screening for the presence or absence of one or more polymorphism alleles in genomic sequence information.