| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more functional groups and a reactive group under conditions allowing the sample molecule to covalently bind to the reactive group on the sample molecule, and cleaving the cleavable functional group to release the sample molecule comprising the one or more functional groups (which can be a tag). SOLUTION: The solid support is covalently coupled to a chemical group comprising a cleavable functional group, a mass spectrometry tag and a reactive group for covalently attaching a sample molecule, wherein the cleavable functional group, the tag and the reactive group are arranged relative to one another to allow transfer of the tag to the sample molecule upon cleavage of the cleavable functional group. COPYRIGHT: (C)2009,JPO&INPIT |
