DIAGNOSTIC AND THERAPEUTIC CYCLOOXYGENASE-2 BINDING LIGANDS
摘要
The present invention provides conjugates useful for the diagnosis and treatment of diseases associated with the over-expression of COX-2. The conjugates comprise a selective COX-2 targeting carrier, a metal coordinating moiety, and a linker chemically linking the metal coordinating moiety to the carrier. The metals coordinated by the metal coordinating moiety are selected from paramagnetic or radioisotopes. The invention also includes kits comprising a conjugate and a radioisotope solution.
申请公布号
WO2008091530(A3)
申请公布日期
2009.08.06
申请号
WO2008US00631
申请日期
2008.01.17
申请人
MALLINCKRODT INC.;HOWARD, CAROL, P.;MOORE, DENNIS, A.