发明名称 |
NOVEL USE OF UBIQUITIN C-TERMINAL HYDROLASE-L1 |
摘要 |
<p>The present invention relates to a composition for diagnosing cancer metastasis comprising Ubiquitin C-terminal hydrolase-L1 (UCH-L1), a use of UCH-L1 for diagnosing cancer metastasis and a method for diagnosing cancer metastasis using the same; a composition for suppressing cancer metastasis comprising an inhibitor of UCH-L1, a use of an inhibitor of UCH-L1 for suppressing cancer metastasis and a method of suppressing cancer metastasis using the same; a composition for screening a cancer metastasis inhibitor comprising UCH-L1 protein, a use of UCH-L1 protein for screening a cancer metastasis inhibitor and a method of screening cancer metastasis inhibitor using the same; a composition for screening a cancer metastasis inhibitor comprising UCH-L1 gene, a use of UCH-L1 gene for screening a cancer metastasis inhibitor, a method of screening cancer metastasis inhibitor using the same. UCH-L1 is a key molecule to modulate cell migration including the cancer invasion according to their expressing level. Thus, the monoclonal and polyclonal antibodies and the substrate of UCH-L1 can be used for diagnosis of cancer metastasis. Also, the cancer metastasis can be suppressed by inhibiting of the expression of UCH-L1 or activity of the enzyme, thus we can screen and develop an inhibitor of UCH-L1 and use it as an adjuvant drug for anticancer therapy.</p> |
申请公布号 |
EP1993581(A4) |
申请公布日期 |
2009.08.05 |
申请号 |
EP20060843893 |
申请日期 |
2006.11.24 |
申请人 |
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION;SK CORPORATION |
发明人 |
LEE, KONG JOO;KIM, HYUN JUNG;CHO, JEONG WOO;MAENG, CHEOL YOUNG;NAM, YOU KYUNG;LIM, SANG MI;KIM, YOUNG MEE |
分类号 |
A61K38/00;A61K31/70 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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