发明名称 |
Methods of preparing polymers having terminal amine groups using protected amine salts |
摘要 |
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
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申请公布号 |
US7569657(B2) |
申请公布日期 |
2009.08.04 |
申请号 |
US20060537172 |
申请日期 |
2006.09.29 |
申请人 |
ENZON PHARMACEUTICALS, INC. |
发明人 |
ZHAO HONG;RUBIO BELEN |
分类号 |
C08F6/06;C08F6/10;C08G73/00 |
主分类号 |
C08F6/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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