Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).
申请公布号
IL194198(D0)
申请公布日期
2009.08.03
申请号
IL20080194198
申请日期
2008.09.18
申请人
MOUNT SINAI SCHOOL OF MEDICINE;THE GOV OF THE USA;YALE UNIVERSITY SCHOOL OF MEDICINE;CHARNEY, DENNIS S;MATHEW, SANJAY J;MANJI, HUSSEINI K;ZARATE, CARLOS A;KRYSTAL, JOHN H