USES OF DPP-IV INHIBITORS

摘要

Use of dipeptidyl peptidase IV inhibitor compound (A) of (I) or (II) and/or their salts for the preparation of medicament to treat a patient with physiological functional disorders such as pre-diabetes, glucose-intolerance, pathological fasting-glucose, diabetic foot, diabetes associated ulcer, diabetic hyperlipidemia, diabetic dyslipidemia, newly diagnosed type 1 diabetes, gestation-diabetes, hyperglycemia, adrenergic postprandial syndrome and cardiac insufficiency, or for therapeutic treatment of a patient with transplanted islet langerhans or beta cell. Use of dipeptidyl peptidase IV inhibitor (A) compound of formula (I) or (II) and/or their salts for the preparation of medicament to treat a patient with physiological functional disorders such as pre-diabetes, glucose-intolerance, pathological fasting-glucose, diabetic foot, diabetes associated ulcer, diabetic hyperlipidemia, diabetic dyslipidemia, newly diagnosed type 1 diabetes, gestation-diabetes, hyperglycemia, adrenergic postprandial syndrome and cardiac insufficiency, or for therapeutic treatment of a patient with transplanted islet langerhans or beta cell. R1 : ([1,5]naphthyridin-2-yl)methyl, (quinazolin-2-yl)methyl, (quinoxalin-6-yl) methyl, (4-methyl-quinazolin-2-yl)methyl, 2-cyano-benzyl, (3-cyano-quinolin-2-yl)methyl, (3-cyano-pyridin-2-yl)methyl, (4-methyl-pyrimidin-2-yl)methyl or (4,6-dimethyl-pyrimidin-2-yl)methyl; and R2 : 3-(R)-amino-piperidin-1-yl, (2-amino-2-methyl-propyl)-methylamine or (2-(S)-amino-propyl)-methylamine. Independent claims are included for: (1) isolation or storage medium for islet langerhans or beta cell, where the medium strengthens vitality and secretion capacity of the cell 1 nmol/l to 1 mu mol/l of (I); and (2) a procedure for strengthening the vitality and secretion capacity of islet langerhans or beta cells comprising adding (I) in a concentration of 1 nmol/l to 1 mu mol/l to the isolation medium or storage medium during the isolation and transplantation phase of the islet langerhans or beta -cells. [Image] - ACTIVITY : Antidiabetic; Metabolic; Antiulcer; Dermatological; Antilipemic; Cardiant; Vasotropic; Antianginal; Cardiovascular-Gen; Antiarrhythmic. - MECHANISM OF ACTION : Dipeptidyl peptidase IV inhibitor.