| 摘要 |
Process for preparing a 2-(ethoxymethyI)-tropane derivative of formula (1) or a pharmaceutically acceptable salt thereof, wherein: R1 denotes hydrogen or C1-6 alkyl; and R2 denotes phenyl optionally mono- or polysubstituted by halogen, trifluoromethyl or cyano; characterised in that a 2-(hydroxymethyl)-tropane derivative of formula (II), wherein R1 and R2 are defined as for formula (I), is reacted with ethyl bromide in the presence of a base, a phase transfer catalyst, and optionally a diluent, and then optionally treated with an acid, and wherein the base is selected from the group consisting of lithium hydroxide, sodium hydroxide and potassium hydroxide.
|
