A biomolecule-containing formulation of increased stability

摘要

Provided is a suspension formulation that is deliverable via an implantable delivery device comprising: a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics; and a dry particle formulation comprising a biomolecule dispersed in the vehicle; characterized in that a first surfactant is incorporated in the vehicle and a second surfactant is incorporated in the dry particle formulation. Further provided are methods of enhancing release of biomolecules, including interferon, in a hydrophilic release rate using the formulation.