Anti-IL2 antibodies

摘要

Provided is a humanized monoclonal antibody or fragment thereof which specifically binds to human interleukin-2 (IL2), wherein said humanized monoclonal antibody neutralizes the activity of human IL2 by binding to said human· lL2 prior to, during, and/or subsequent to the binding of said human IL2 to the human IL2-receptor, and wherein the light chain variable region of said humanized monoclonal antibody comprises in its second framework region the contiguous amino acid sequence KAPKA wherein the light and heavy chain variable regions further comprise in its CDR1, CDR2 and CDR3 a specified amino acid sequence. Further provided are uses of the compositions in the manufacture of medicament to treat inflammatory diseases.