摘要 |
Substituted pyridines and pyridazines having angiogenesis inhibiting activity and generalized structural formula (I) wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R<1> and R<2> may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermeability processes using these materials are also disclosed. |
申请人 |
BAYER PHARMACEUTICALS CORPORATION |
发明人 |
DUMAS, JACQUES, P.;JOE, TEDDY, KITE;KLUENDER, HAROLD, C., E.;LEE, WENDY;NAGARATHNAM, DHANAPALAN;SIBLEY, ROBERT, N.;SU, NING;BOYER, STEPHEN, JAMESITY;DIXON, JULIE, A. |