3-Cyano-quinoline derivatives with antiproliferative activity

摘要

Disclosed is a compound of formula (I), or an N-oxide, pharmaceutically acceptable addition salt or stereoisomer thereof, where Z is O, NH, or S, and the other substituents are as disclosed in the specification. Also disclosed is a process for preparing the compound, and its use in treating cell proliferative disorders such as atherosclerosis, restenosis, and cancer.