| 摘要 |
Disclosed is a method for diagnosing and monitoring a disease or condition by quantifying markers, wherein said marker is: (i) a truncated disease-associated protein lacking its two N-terminal amino acids and lacking only these two amino acids from the N-terminus; (ii) a truncated disease-associated protein lacking its two C-terminal amino acids and lacking only these two amino acids from the C-terminus; (iii) a truncated disease-associated protein lacking its two N-terminal amino acids and its two C-terminal amino acids and lacking only these two amino acids from the N-terminus and two amino acids from the C-terminus; (iv) a diketopiperazine (DKP) comprising the two N-terminal amino acids of a disease-associated protein, wherein the DKP is not His-Pro DKP; or (v) a DKP comprising the two C-terminal amino acids of a disease associated protein wherein the disease associated protein is myelin basic protein, beta amyloid, Rh factor, pulmonary surfactant associated protein A, pulmonary surfactant associated protein B, pulmonary surfactant associated protein D, insulin, tau protein, alpha synuclein, C reactive protein, interleukin 8, S100 proteins, beta chorionic gonadotropin, fetal erythropoietin, pregnancy associated protein A, myoglobin, troponin I, troponin T, prostate specific antigen, amylase, lipase, alpha1 antitrypsyn, erthyropoietin, activated protein C, tethal chain, zeta chain, alpha chain, beta chain, delta chain, epsilon chain, or gamma AG. Also disclosed are binding partners specific for the markers and compositions and kits for conducting the methods of the invention.
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