BIVALENT ERBB LIGAND BINDING MOLECULES AND METHODS FOR THEIR PREPARATION AND USE
摘要
A new bivalent ErbB-based ligand binding molecule is disclosed along with its method of preparation and use. The binding molecule can be a protein expressed from a recombinant DNA molecule. The protein can contain two extracellular domains of an ErbB receptor that both bind to ErbB receptor ligands. These binding molecules act as traps to bind and sequester ligands, thus making them unavailable for binding to cellular ErbB receptors.
申请公布号
WO2007092932(A8)
申请公布日期
2009.07.30
申请号
WO2007US61863
申请日期
2007.02.08
申请人
TARGETED MOLECULAR DIAGNOSTICS, LLC;YEDA RESEARCH AND DEVELOPMENT CO. LTD.;BACUS, SARAH S.;HILL, JASON, E.;YARDEN, YOSEF;KOCHUPURAKKAL, BOSE, S.
发明人
BACUS, SARAH S.;HILL, JASON, E.;YARDEN, YOSEF;KOCHUPURAKKAL, BOSE, S.