发明名称 |
POLYNUCLEOTIDE OR ANALOGUE THEREOF, AND GENE EXPRESSION REGULATION METHOD USING THE POLYNUCLEOTIDE OR THE ANALOGUE THEREOF |
摘要 |
<p>The object is to provide a gene expression regulation method for regulating the expression of a target gene, which can up-regulate the expression of a product of the target gene. Disclosed is a polynucleotide or an analogue thereof, wherein the polynucleotide comprises a nucleotide sequence complementary to at least a part of cis-element of mRNA and a nucleotide sequence complementary to a part of the 5'- and/or 3'-untranslated region of the cis-element, and can bind specifically to at least a part of the cis-element due to the sequence specificity of the nucleotide sequence complementary to the untranslated region to thereby inhibit the binding of a cis-element-binding factor to the cis-element. The polynucleotide or the analogue thereof can inhibit the binding of a cis-element-binding factor to the cis-element, and therefore can stabilize the mRNA selectively to promote the translation into the gene product or can unstabilize the mRNA selectively to inhibit the translation into the gene product.</p> |
申请公布号 |
WO2009093384(A1) |
申请公布日期 |
2009.07.30 |
申请号 |
WO2008JP72088 |
申请日期 |
2008.12.04 |
申请人 |
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY;NATSUME, TORU;ADACHI, SHUNGO;IEMURA, SHUNICHIRO |
发明人 |
NATSUME, TORU;ADACHI, SHUNGO;IEMURA, SHUNICHIRO |
分类号 |
C12N15/09;A61K31/7105;A61P3/04;A61P3/06;A61P3/10;A61P9/00;A61P9/10;A61P9/12;A61P35/00;C07H21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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