PROTEIN STRUCTURE AND METHOD OF USING PROTEIN STRUCTURE
摘要
<p>Methods for building an atomic model of a protein molecule comprising: (a) identifying a protein molecule with at least 20% sequence identity with Microsomal Prostaglandin E Synthase 1 (MPGES1) and (b) utilizing the atomic coordinates of MPGES1 to obtain an atomic model of the identified protein molecule and methods for determining a drug candidate compound that interacts with members of the MAPEG family, in particular MPGES1, are also provided.</p>