GENE DISRUPTION, COMPOSITION, AND METHOD RELATING THERETO

摘要

PROBLEM TO BE SOLVED: To provide gene disruptions, compositions, and method relating thereto. SOLUTION: A transgenic animals, as well as compositions and methods relating to the characterization of gene function are disclosed. Specifically, a transgenic mice comprises disruptions in genes described in the specification. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. COPYRIGHT: (C)2009,JPO&INPIT