发明名称 |
COMPOUNDS HAVING CRTH2 ANTAGONIST ACTIVITY |
摘要 |
<p>Compounds of general formula (I): wherein W is chloro or fluoro; Z is a group SO2R1; wherein R1 is -C3-C8 cycloalkyl or heterocyclyl optionally substituted with one or more substituents chosen from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)POR2, and - O(CH2)pO(CH2)qOR2 wherein each R2 is independently hydrogen, -Ci-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.</p> |
申请公布号 |
WO2009093029(A1) |
申请公布日期 |
2009.07.30 |
申请号 |
WO2009GB00175 |
申请日期 |
2009.01.22 |
申请人 |
OXAGEN LIMITED;ARMER, RICHARD, EDWARD;MAILLOL, CAROLE, ELIANE, ANDREE;DORGAN, COLIN, RICHARD;WYNNE, GRAHAM, MICHAEL;VILE, JULIA |
发明人 |
ARMER, RICHARD, EDWARD;MAILLOL, CAROLE, ELIANE, ANDREE;DORGAN, COLIN, RICHARD;WYNNE, GRAHAM, MICHAEL;VILE, JULIA |
分类号 |
C07D209/10;A61K31/404;A61P11/06;A61P17/06 |
主分类号 |
C07D209/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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