摘要 |
Cell-based screens for compounds that inhibit the accumulation of amyloids are described. For example, the herein described screens may be used to assay the formation, or inhibition, of pre- amyloid or amyloid aggregates and/or oligomers. Agents have been identified that interfere with, or inhibit, the oligomerization of the major component of amyloid plaques; a 42 amino acid long Aß42 peptide product of proteolytic processing of the APP protein.
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申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;LIEBMAN, SUSAN, W.;BAGRIANTSEV, SVIATOSLAV, N. |
发明人 |
LIEBMAN, SUSAN, W.;BAGRIANTSEV, SVIATOSLAV, N. |