发明名称 |
PHARMACEUTICAL COMPOSITION COMPRISING ANTI-MIRNA ANTISENSE OLIGONUCLEOTIDES |
摘要 |
<p>The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.</p> |
申请公布号 |
WO2007112753(A8) |
申请公布日期 |
2009.07.30 |
申请号 |
WO2007DK00168 |
申请日期 |
2007.03.30 |
申请人 |
SANTARIS PHARMA A/S;ELMEN, JOACIM;KEARNEY, PHIL;KAUPPINEN, SAKARI |
发明人 |
ELMEN, JOACIM;KEARNEY, PHIL;KAUPPINEN, SAKARI |
分类号 |
A61K31/712;A61P3/06;A61P3/10;A61P9/10;A61P31/14;A61P35/00;C07H21/00;C12N15/113 |
主分类号 |
A61K31/712 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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