MARKER GENE FOR EXAMINING PSORIASIS VULGARIS

摘要

It is intended to identify a novel psoriasis vulgaris-sensitive gene by a mapping method using microsatellites at a high efficiency and a low cost. Namely, a novel psoriasis vulgaris-sensitive gene such as OR2J3 gene or IGSF4D gene in human genomic DNA sequence has been identified by conducting a case control correlation analysis relating to psoriasis vulgaris with the use of microsatellite polymorphism markers, which are designed at intervals of about 100 kb, narrowing down candidate regions and then conducting a correlation analysis and a chain analysis with the use of SPNs as markers.