发明名称 THERAPEUTIC VACCINES
摘要 A first aspect of the invention relates to a conjugate comprising: (i) mannan; and (ii) at least one epitope comprising a peptide fragment of a protein selected from myelin basic protein (MBP), myelin oligodentrocyte glycoprotein (MOG) and proteolipid protein (PLP), said peptide fragment being in linear or cyclic form; wherein said epitope is linked to mannan via a [(LyS-GIy)n] bridge, where n is an integer from 1 to 10. Further aspects of the invention relate to pharmaceutical compositions comprising said conjugates, and their use in the preparation of a medicament for treating an immune disorder.
申请公布号 WO2009093143(A2) 申请公布日期 2009.07.30
申请号 WO2009IB00382 申请日期 2009.01.22
申请人 ELDRUG S.A.;MATSOUKAS, JOHN;TSELIOS, THEODORE;APOSTOLOPOULOS, VASSO;TSEVELEKI, VIVIAN;KATSARA, MARIA;PROBERT, LESLEY 发明人 MATSOUKAS, JOHN;TSELIOS, THEODORE;APOSTOLOPOULOS, VASSO;TSEVELEKI, VIVIAN;KATSARA, MARIA;PROBERT, LESLEY
分类号 A61K39/00;A61K39/39 主分类号 A61K39/00
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