| 摘要 |
<p>Dihydropyridine calcium antagonist compounds, preparation methods and medical uses thereof are disclosed. Particularly, preparation methods of compounds of general formula (I) and (II) and pharmaceutically acceptable salts thereof, and their uses in the treatment of cardiovascular diseases are disclosed, wherein R1 represents substituted or unsubstituted heterocyclic, aromatic ring or aralkyl group, the substituents may be C1-C4alkyl, C1-C4alkoxyl, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro, amino or hydroxyl; R2 represents C1-C8alkyl; R3 and R4 may be same or different, and each independently represents hydrogen, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro, amino or C1-C4alkyl, C1-C4alkoxyl, C1-C4alkenyl, C1-C4alkynyl; R5 and R6 are same or different, and each represents C1-C4alkyl; X represents O, S or a single bond; m=0-6, n=1-6, and m and n may be same or different.</p> |
