发明名称 |
SYSTEM FOR RAPID PRODUCTION OF HIGH-TITER AND REPLICATION-COMPETENT ADENOVIRUS-FREE RECOMBINANT ADENOVIRUS VECTORS |
摘要 |
<p>The present invention relates generally to the fields of gene therapy, immunology, and vaccine technology. More specifically, the invention relates to a novel system that can rapidly generate high titers of adenovirus vectors that are free of replication-competent adenovirus (RCA). Also provided are methods of generating these RCA-free adenoviral vectors, immunogenic or vaccine compositions comprising these RCA-free adenovirus vectors, methods of expressing a heterologous nucleic acid of interest in these adenovirus vectors and methods of eliciting immunogenic responses using these adenovirus vectors.</p> |
申请公布号 |
EP1899470(A4) |
申请公布日期 |
2009.07.29 |
申请号 |
EP20060760400 |
申请日期 |
2006.05.23 |
申请人 |
VAXIN, INC. |
发明人 |
VAN KAMPEN, KENT R.;ZHANG, JIANFENG;TANG, DE-CHU C. |
分类号 |
A61K39/145;A61K48/00;C07K14/11;C12N7/00;C12N15/861 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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