SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES WITH BLEACHING OF INTERMEDIATE FLUORESCENT SIGNALS
摘要
Methods for detecting multiple targets in a biological sample are provided. The methods include (a) contacting the sample with a first probe; (b) physically binding the first probe to a first target; (c) detecting a first signal from the first probe; (d) applying a chemical agent to modify the first signal; (e) contacting the sample with a second probe; (f) physically binding the second probe to a second target; and (g) detecting a second signal from the second probe. An associated kit and device are also provided.
申请公布号
EP2082230(A2)
申请公布日期
2009.07.29
申请号
EP20070874282
申请日期
2007.11.15
申请人
GENERAL ELECTRIC COMPANY
发明人
FILKINS, ROBERT JOHN;MONTALTO, MICHAEL CHRISTOPHER;SOOD, ANUP;GERDES, MICHAEL J.;SEEL, MAXIMILIAN LEWIS