The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors having the structure shown below: wherein R and R1 are as defined herein. The 2-arylamino-4 -(aminoalkylene)aminopyrimidines inhibit Protein Kinase C-alpha (PKC-α). The PKC-α inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4 -(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.
申请公布号
ZA200809945(B)
申请公布日期
2009.07.29
申请号
ZA20080009945
申请日期
2008.11.24
申请人
BOEHRINGER INGELHEIM INTERNATIONAL GMBH.
发明人
DJUNG, JANE, FAR-JINE;GOLEBIOWSKI, ADAM;HUNTER, JACK, A.;SHRUM, GARY, P.