发明名称 |
PROCESS FOR PRODUCTION OF PHENYLALANINE DERIVATIVES HAVING QUINAZOLINEDIONE SKELETONS AND INTERMEDIATES FOR THE PRODUCTION. |
摘要 |
<p>A process for the production of phenylalanine derivatives having quinazolinedione rings as represented by the general formula (1) or pharmaceutically acceptable salts thereof:(1) which comprises the following steps (a), (b) and (c): the step (a) of reacting an acylphenylalanine derivative represented by the general formula (2): (2) with a carbonyl-introducing agent and a specific anthranilic acid derivative to form a corresponding carboxy asymmetric urea derivative, the step (b) of converting the carboxy asymmetric urea derivative into a corresponding quinazolinedione in the presence of a carboxyl-activating agent, and the optional step (c) comprising the N-alkylation step of replacing the hydrogen atom attached to the nitrogen atom constituting the quinazoline- dione ring by an alkyl group with an N-alkylating agent and/or the deblocking step of deblocking R3' (a group corresponding to R3) when R3' is in a protected state. According to the process, phenylalanine derivatives having quinazolinedione skeletons can be produced in high yield favorable for industrialization.</p> |
申请公布号 |
MX2009005440(A) |
申请公布日期 |
2009.07.29 |
申请号 |
MX20090005440 |
申请日期 |
2007.11.22 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
KATAOKA, NORIYASU;OKUZUMI, TATSUYA;YAMADA, TATSUHIRO;SUGIKI, MASAYUKI;SUZUKI, TAMOTSU;OKADO, KOTARO;FUJITA, KOICHI;TATARA, AKINORI |
分类号 |
C07D239/96;C07C233/51;C07C237/40;C07C265/12;C07C271/22;C07C271/28;C07C275/42 |
主分类号 |
C07D239/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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