发明名称 |
ADIPONECTIN EXPRESSION INDUCER AND UTILIZATION OF THE SAME |
摘要 |
The present invention provides adiponectin expression-inducing agents, and therapeutic agents using the same for obesity and obesity-related diseases such as cardiovascular diseases or metabolic diseases, as well as methods of searching for adiponectin expression-inducing agents. KLF9, which can bind to the 32-bp fragment of position -188 to position -157 from the adiponectin expression start site, was demonstrated to enhance adiponectin promoter activity. Therefore, the present invention uses KLF9 as an adiponectin expression-inducing agent, and suggests that KLF9 replenishment therapy is useful for preventing and/or treating obesity or obesity-related diseases including metabolic diseases such as insulin resistance and type II diabetes, and cardiovascular diseases. |
申请公布号 |
EP1757302(A4) |
申请公布日期 |
2009.07.29 |
申请号 |
EP20050727594 |
申请日期 |
2005.03.31 |
申请人 |
TOUDAI TLO, LTD.;NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
KADOWAKI, TAKASHI;YAMAUCHI, TOSHIMASA;KITAJIMA, SHOKO;ITO, YUSUKE |
分类号 |
A61K38/00;A61K38/17;A61K48/00;A61P3/00;A61P3/10;A61P9/00;C12N5/10;C12Q1/02;G01N33/15;G01N33/68;G01N33/92 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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