<p>Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.</p>
申请公布号
EP1846024(A4)
申请公布日期
2009.07.29
申请号
EP20060733693
申请日期
2006.01.12
申请人
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, A DIVISION OF YESHIVA UNIVERSITY
发明人
JACOBS, WILLIAM, R., JR.;PORCELLI, STEVEN, A.;BRIKEN, VOLKER;BRAUNSTEIN, MIRIAM