发明名称 |
METHOD FOR ENHANCING BONE FORMATION |
摘要 |
This invention provides a method for facilitating bone formation in a subject comprising delivering to a bone formation-requiring site a composition of matter comprising platelet-rich plasma, calcium, a PAR-activating agent and a bone forming material. This invention further provides a method for facilitating bone formation in a subject comprising (a) delivering to a bone formation-requiring site in the subject a composition of matter comprising platelet-rich plasma, calcium and a bone-forming material, and (b) contacting the composition so delivered with a PAR-activating agent other than thrombin. This invention further provides a method for facilitating clot formation in platelet-rich plasma with a PAR-activating agent other than thrombin. This invention further provides a method of producing a formable gel comprising the step of admixing platelet-rich plasma, calcium, a bone-forming material and a PAR-activating agent other than thrombin. Finally, this invention provides related compositions of matter and articles of manufacture. |
申请公布号 |
EP1781319(A4) |
申请公布日期 |
2009.07.29 |
申请号 |
EP20050776579 |
申请日期 |
2005.07.30 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
LANDESBERG, REGINA;PINSKY, DAVID J.;KATZ, RONALD W. |
分类号 |
A61K9/50;A61K38/16;A61K38/17;A61K38/18 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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