OLIGO PEPTIDE-DERIVED NOVEL CATIONIC LIPID, A PREPARATION METHOD OF THE SAME AND A DELIVERY SYSTEM COMPRISING THE SAME

摘要

A cationic lipid is provided to ensure high profitability in mass production due to convenient manufacture and purification process, and to improve therapeutic efficacy of nucleic medicine by reducing cytotoxin. A cationic lipid has a structure represented by chemical formula (I). In chemical formula (I), n is an integer of 3-6; and R is C12-20 unsaturated hydrocarbon radical. An oligonucleic acid delivery system inside cells comprises the cationic lipid. The oligo nucleic acid is selected from the group consisting of ribonucleic acid, small interfering ribonucleic acid(siRNA), antisense oligonucleotide and nucleic acid aptamer. The delivery system formulation of the oligo nucleic acid is selected from the group consisting of liposomes, micelles, emulsions and nanoparticles.