发明名称 |
Humanized anti-CCR2 antibodies and methods of use therefor |
摘要 |
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
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申请公布号 |
US7566450(B2) |
申请公布日期 |
2009.07.28 |
申请号 |
US20070924794 |
申请日期 |
2007.10.26 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
LAROSA GREGORY J.;HORVATH CHRISTOPHER J.;NEWMAN WALTER;JONES S. TARRAN;O'BRIEN SIOBHAN H.;O'KEEFE THERESA |
分类号 |
A61K39/395;G01N33/53;A61P9/10;A61P29/00;A61P31/18;A61P37/02;A61P43/00;C07K16/00;C07K16/28;C12N5/10;C12N15/02;C12N15/09;C12P21/08;C12Q1/02;C12R1/91;G01N33/566;G01N33/577 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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