PLCbeta4 MUTANT MICE AS A MODEL FOR TESTING ANXIETY DISORDER DRUGS

摘要

Provided are a method or a use of using a PLC beta4 knock-out animal as an anxiety disorder animal model, and a method of screening anxiety disorder-preventing and treating agents using the animal. A method of using a PLC beta4 knock-out animal as an anxiety disorder animal model comprises using an animal in which a PLC beta4(phospholipase beta4) gene representing a lack in the memory disappearing capability is knocked-out as an anxiety disorder animal model. A use of using a PLC beta4 knock-out animal as an anxiety disorder animal model comprises using an animal in which a PLC beta4(phospholipase beta4) gene representing a lack in the memory disappearing capability is knocked-out as an anxiety disorder animal model. A method of screening anxiety disorder-preventing and treating agents comprises the steps of: injecting candidate materials of the anxiety disorder-preventing and treating agents into an animal in which a PLC beta4(phospholipase beta4) gene is knocked-out; testing the memory disappearing capability of the animal; and sorting the candidate material that has attentively recovered the memory disappearing capability as compared with a control group into which the candidate materials have not been injected.