发明名称 POLYMORPHS OF A MGLUR5 RECEPTOR ANTAGONIST
摘要 Present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations. Present compounds are active on the mGluR5 receptor for the treatment of diseases, related to this receptor, such acute and/or chronic neurological disorders, in particular anxiety, or for the treatment of chronic and acute pain, protection against liver damage, failure whether drug or disease induced, urinary incontinence, obesity, Fragile-X or Autism.
申请公布号 KR20090081026(A) 申请公布日期 2009.07.27
申请号 KR20097012810 申请日期 2007.12.11
申请人 F. HOFFMANN-LA ROCHE AG 发明人 CLEARY THOMAS P.;GLOMME ALEXANDER;GRASSMANN OLAF;KUANG SHAN MING;MEIER ROLAND;MILLER DOREEN;MOOG REGINA;ROHRER FRANZISKA E.;YANG JASON
分类号 C07D401/06;A61K31/4439;A61P25/00 主分类号 C07D401/06
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