发明名称 |
SOLUBLE CTLA4 MUTANT MOLECULES AND USES THEREOF |
摘要 |
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first arnino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule. |
申请公布号 |
UA87432(C2) |
申请公布日期 |
2009.07.27 |
申请号 |
UA20021210563 |
申请日期 |
2001.05.23 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
PEACH ROBERT J.;NAEMURA JOSEPH R.;LINSLEY PETER S.;BAJORATH JURGEN |
分类号 |
C07K14/705;C12N15/09;A61K38/00;A61K45/00;A61P37/00;A61P37/06;C07K;C07K14/47;C07K16/00;C07K19/00;C12N5/10;C12P21/02;C12Q1/02;G01N33/68 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|