Disclosed is a humanized anti-human a9-integrin antibody having improved activities and/or physical properties compared with a donor mouse anti-human a9-integrin antibody. Specifically disclosed are: a humanized anti-human a9-integrin antibody having a heavy-chain variable region comprising the amino acid sequence depicted in SEQ ID NO:11 and a light-chain variable region comprising the amino acid sequence depicted in SEQ ID NO:17; a humanized anti-human a9-integrin antibody having a heavy-chain variable region comprising the amino acid sequence depicted in SEQ ID NO:13 and a light-chain variable region comprising the amino acid sequence depicted in SEQ ID NO:17; and a humanized anti-human a9-integrin antibody having a heavy-chain variable region comprising the amino acid sequence depicted in SEQ ID NO:15 and a light-chain variable region comprising the amino acid sequence depicted in SEQ ID NO:9. Also disclosed is a means for preventing or treating a disease of which human a9-integrin is involved in the development of the disease condition, which utilizes the antibody.
申请公布号
CA2711882(A1)
申请公布日期
2009.07.16
申请号
CA20092711882
申请日期
2009.01.09
申请人
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE;ASTELLAS PHARMA INC.