ORAL CONTROLLED RELEASE COATED TABLET

摘要

An oral, controlled release coated tablet having one or more surfaces, the coated tablet comprising: a core comprising a drug composition comprising metoprolol or its pharmaceutically acceptable salt, pH dependent polymer that is soluble in water at a pH below 5 and a copolymer of methacrylic acid and methacrylate and; a composition selected from a swellable composition and a reactive composition located in the immediate vicinity of one or more preselected surfaces and; a coating surrounding the core, wherein the coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet.upon contact with an aqueous environment, but not removed from at least one of the surfaces.