发明名称 |
INFLAMMATION TREATMENT, DETECTION AND MONITORING VIA TREM-1. |
摘要 |
<p>The present invention provides methods of treating inflammatory diseases/disorders in a subject by inhibiting/antagonizing TREM-1 expression/activity/signal transduction and/or DAP12/TyroBP expression and/or activity. Methods of detecting the presence of inflammatory disease in a subject by detecting TREM-1 and/or DAP12/TyroBP expression and/or activity in the subject or a sample obtained therefrom, wherein increased expression or activity is indicative of the inflammatory disease are also included. The present invention further provides methods for assessing the efficacy of a TREM-1 -modulating agent administered to a patient by detecting levels of secreted phosphoprotein 1 (SPPl) and/or one or more other biomarkers in the patient or in a sample from the patient.</p> |
申请公布号 |
MX2009007368(A) |
申请公布日期 |
2009.07.16 |
申请号 |
MX20090007368 |
申请日期 |
2008.01.16 |
申请人 |
WYETH. |
发明人 |
LIH-LING LIN;DAVID WINKLER;CARA WILLIAMS;JEFFREY L. FELDMAN;DEBRA D. PITTMAN;JUN KUAI;KEN DOWER;MOITREYEE CHATTERJEE-KISHORE;SCOTT ALAN JELINSKY |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|