HOST RANGE CHANGE PHAGE

摘要

The invention relates to a method of producing an antibacterial composition comprising: (i) culturing a first form of phage in a first bacterial host strain to produce multiplied phage having a first host range; (ii) culturing the multiplied phage in a second bacterial host strain to produce an improved host range phage having an expanded host range; and (iii) mixing the improved host range phage with a second form of phage to produce a panel of phage. Preferably Staphylococcus aureus strain SAI 656 and SAI 661 are used (NCTC 13426 and NCTC 134250.